How Should We Assess the Endometrium of Infertile Patients? What Does the Future Look Like?

Abstract

Attempts at assessing endometrial receptivity through its transcriptomic signature have unfortunately failed. On the contrary, RCTs have indicated that the period of receptivity is fairly wide, lasting 48–72 hours. Today, the ultimate challenge is to optimize hormonal preparation for frozen embryo transfers (FETs). Recent data have provided compelling evidence that vaginal progesterone provides insufficient plasma levels of progesterone in a large fraction of patients, which leads to lower live birth rates and increased risks of miscarriage. The most efficient option consists in delivering injectable progesterone, or opting for a combo approach associating vaginal and injectable progesterone.