CRITERIA FOR AN UPDATED CLASSIFICATION OF HUMAN TRANSCRIPTION FACTOR DNA-BINDING DOMAINS-Reference-Cited by-同舟云学术

CRITERIA FOR AN UPDATED CLASSIFICATION OF HUMAN TRANSCRIPTION FACTOR DNA-BINDING DOMAINS

Published:2013-02 Issue:01 Volume:11 Page:1340007
ISSN:0219-7200
Container-title:Journal of Bioinformatics and Computational Biology
language:en
Short-container-title:J. Bioinform. Comput. Biol.

Author:

WINGENDER EDGAR¹²

Affiliation:

1. Department of Bioinformatics, University Medical Center Göttingen, Goldschmidtstr. 1, Göttingen, D-37077, Germany

2. geneXplain GmbH, Am Exer 10B, Wolfenbüttel, D-38302, Germany

Abstract

By binding to cis-regulatory elements in a sequence-specific manner, transcription factors regulate the activity of nearby genes. Here, we discuss the criteria for a comprehensive classification of human TFs based on their DNA-binding domains. In particular, classification of basic leucine zipper (bZIP) and zinc finger factors is exemplarily discussed. The resulting classification can be used as a template for TFs of other biological species.

Publisher

World Scientific Pub Co Pte Ltd

Subject

Computer Science Applications,Molecular Biology,Biochemistry

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0219720013400076

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