Study on FAIMS ion source control and optimization using over-electric field

Author:

Zhong Lunchao1,Gong Tao1,Ma Hui2,Shi Wenyan1,Wang Peirong1,Zhou Jinli1,Deng Jun3,Guo Jiahu3

Affiliation:

1. Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518000, P. R. China

2. School of Materials and Environmental Engineering, Chengdu Technological University, Chengdu 611730, P. R. China

3. Academy of ESH, Sichuan Staff University of Science and Technology, Chengdu 610101, P. R. China

Abstract

Ion source provides sample ions for FAIMS. The key technology is ionization method. Efficient ionization of analytes is the core technology for data acquisition in high quality FAIMS systems. In order to long-distance detect and analyze harmful and toxic substances such as explosives, drugs, chemical reagents and environmental pollutants in an open environment, without pretreatment, real-time and on-line, the ion source control and its technical device using excessive electric field were designed and developed. The disadvantages of high flow rate of APCI and low flow rate of ESI are integrated, based on the chemical analysis principle of FAIMS, an experimental platform of ionization technology based on excessive electric field is proposed and designed, which mainly includes: ion focusing system, flat-panel migration zone with focusing structure, sample integration, etc. The experimental results show that the ion source based on excessive electric field can be widely used in biochemical weapon warning, drug tablet detection, environmental monitoring, food and drug detection and clinical medicine, and the detection limit can reach 0.1 ppm.

Funder

Shenzhen Free Exploration Project for Basic Research of Science and Technology Program

Safety Production Technology Project of Sichuan Province

Education Reform Project of Sichuan Province

Chengdu Technological University Start-up Project of Introducing Talents

Research Project of Sichuan Staff University of Science & Technology

Publisher

World Scientific Pub Co Pte Lt

Subject

Condensed Matter Physics,Statistical and Nonlinear Physics

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