Single nucleotide polymorphism genotyping using DNA sequencing on multiwalled carbon nanotubes monolayer by CNT-plasmon resonance

Author:

Grushevskaya H. V.1,Krylova N. G.1,Lipnevich I. V.1,Egorova V. P.2,Babenka A. S.3

Affiliation:

1. Physics Department, Belarusian State University, 4 Nezalezhnasti Ave., 220030 Minsk, Belarus

2. Belarusian State Pedagogical University, 18 Sovetskaya Str., 220030 Minsk, Belarus

3. N.N. Alexandrov National Cancer Centre of Belarus, 223040 Lesnoy, Minsk District, Belarus

Abstract

DNA-nanosensor based on multiwalled carbon nanotubes (MWCNTs) decorated by nanocyclic thiophene-pyrrole complexes of octahedral high-spin Fe has been proposed for high-performance sensing of DNA-hybridization utilizing a surface-enhanced spin-dependent CNT-plasmon resonance. This DNA-nanosensor operates on screening and quenching effects at Raman scattering of light in duplexes DNA-probe/DNA-target at complementary pairing of nucleotides in DNA. Single nucleotide polymorphism (SNP) genotyping has been successfully performed for DNA samples from healthy and cancer-suffering donors.

Publisher

World Scientific Pub Co Pte Lt

Subject

Condensed Matter Physics,Statistical and Nonlinear Physics

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