DIFFERENTIAL RESPONSES OF COPPER(I) AND COPPER(II) ON LIVER COPPER ACCUMULATION IN THE LONG-EVANS CINNAMON (LEC) RATS STUDIED BY PIXE DETERMINATION-Reference-Cited by-同舟云学术

DIFFERENTIAL RESPONSES OF COPPER(I) AND COPPER(II) ON LIVER COPPER ACCUMULATION IN THE LONG-EVANS CINNAMON (LEC) RATS STUDIED BY PIXE DETERMINATION

Published:2000-01 Issue:03n04 Volume:10 Page:155-159
ISSN:0129-0835
Container-title:International Journal of PIXE
language:en
Short-container-title:Int. J. PIXE

Author:

Ohta A.¹,Bu G.²,Matsubayashi T.¹,Mihara H.³,Nemoto N.⁴,Miyazawa S.⁴,Furukawa K.⁴,Katou T.⁴,Oda E.⁴,Sera K.⁵,Futatsugawa S.⁶,Hatakeyama S.⁶,Saitou Y.⁶

Affiliation:

1. Department of Radiology, Kitasato University School of Medicine, Kitasato, Sagamihara, Kanagawa 228-8555, Japan

2. Norman Bethune University for Medical Science, Xinmin Dajae, Chungchun, 130021, P. R. China

3. Animal Science, Kitasato University School of Medicine, Kitasato, Sagamihara, Kanagawa 228-8555, Japan

4. Electron Microscopy, Kitasato University School of Medicine, Kitasato, Sagamihara, Kanagawa 228-8555, Japan

5. Cyclotron Research Center, Iwate Medical University, 348-58 Tomegamori, Takizawa, Iwate, 020-0173, Japan

6. Nishina Memorial Cyclotron Center, Japan Radioisotope Association, 348-58 Tomegamori, Takizawa, Iwate, 020-0173, Japan

Abstract

Effects of supplementation by copper(I) and copper (II) in Long-Evans Cinnamon(LEC) rats and life survival of rats are given. Long-Evans Cinnamon(LEC) strain rats were used at age of 8 weeks. The rats were randomly assigned to either copper(I) chloride or copper (II) chloride group. We have performed x-ray emissivite determination of copper in liver of LEC rats using PIXE and detected increase in copper in liver at early stage which could be supplemented by copper(I) and copper (II). During the supplementation period, clinical deterioration continued accompanied by daily body sway. The rats lost an undetermined amount of body weight and died approximately fourteen days later.

Publisher

World Scientific Pub Co Pte Lt

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0129083500000213

Reference6 articles.

1. Y. Li, Y. Togashi and N. Takechi, The LEC Rat, A New Model for Hepatitis and Liver Cancer, eds. M. Mori (Springer-Verlag, Tokyo, 1991) pp. 122–132.

2. PIXE DETERMINATION ON THE CHANGES IN THE COPPER CONTENT IN LIVERS OF LONG-EVANS CINNAMON (LEC) RATS FOLLOWING SUPPLEMENT WITH IRON AND CALCIUM

3. THE TAKIZAWA PIXE FACILITY COMBINED WITH A BABY CYCLOTRON FOR POSITRON NUCLEAR MEDICINE

4. Bio-PIXE AT THE TAKIZAWA FACILITY (Bio-PIXE WITH A BABY CYCLOTRON)

5. A FEW APPROACHES TO REMOVE AMBIGUOUS FACTORS IN X-RAY SPECTRUM ANALYSIS

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Quantitative analysis of very small quantities of cultured cells;International Journal of PIXE;2015-01