IN-VIVO ELEMENTAL ANALYSIS BY PIXE-μ-CT

Author:

KAWAMURA Y.1,ISHII K.12,YAMAZAKI H.2,MATSUYAMA S.1,KIKUCHI Y.1,YAMAGUCHI T.1,WATANABE Y.1,OYAMA R.1,MOMOSE G.1,ISHIZAKI A.1,TSUBOI S.1,YAMANAKA K.1,WATANABE M.1

Affiliation:

1. Department of Quantum Science and Energy Engineering, Tohoku University, Aramaki-Aza-Aoba 6-6-01-2, Aoba-ku, Sendai 980-8579, Japan

2. The Archeological Research Center on the Campus of Tohoku University, Katahira 2-1-1, Aoba-ku, Sendai 980-8577, Japan

Abstract

We have developed “micron-CT”, using micro-PIXE for in-vivo imaging. This system comprises an X-ray CCD camera (Hamamatsu photonics C8800X9) with high resolution (pixel size: 8×8 μm 2, number of pixels: 1000×1000) and an X-ray-point-source with a spot size of 1.5×1.5 μm 2 which is generated by irradiation of a microbeam on a pure metal target. Thus we can acquire projection data with high resolution. The sample is placed in a small diameter tube and is rotated by a stepping motor. The 3D images were reconstructed from the obtained projection data by using cone-beam CT reconstruction algorithm. X-ray spectra produced by heavy charged particle bombardment, exhibit a much smaller continuous background compared to electron bombardment. Therefore, X-rays produced by ion beam can be used as a monochromatic and low energy X-ray source. The feature is very effective to investigate small insects. Moreover we can get elemental distribution image of object by choosing appropriate characteristic X-rays corresponding to the absorption edge. On the other hand, the conventional X-ray CT, in which continuous X-rays are used, provides images of the electron density in the object. Using this system, we were able to get 3D images of a living ant's head with 6 μm spatial resolution. By using Fe - K -X-rays (6.40 keV) and Co - K -X-rays (6.93 keV), we can investigate the 3D distribution of Mn ( K -absorption edge = 6.54 keV) in an ant's head.

Publisher

World Scientific Pub Co Pte Lt

Cited by 8 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Development of 3D imaging systems using ion microbeams;Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms;2020-11

2. Particle-Induced X-Ray Emission (PIXE);Encyclopedia of Analytical Chemistry;2016-12-21

3. Micron X-ray computed tomography based on micro-particle-induced X-ray emission;International Journal of PIXE;2015-01

4. 3D imaging of human cells using PIXEμCT;International Journal of PIXE;2014-01

5. In vivo 3D imaging of Drosophila melanogaster using PIXE-micron-CT;X-Ray Spectrometry;2011-03-24

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