Kestose Increases the Relative Abundance of <i>Faecalibacterium</i> spp. and Nominally Increases Cow Milk Tolerant Dose in Children with Cow's Milk Allergy – Preliminary Results-Reference-Cited by-同舟云学术

Kestose Increases the Relative Abundance of Faecalibacterium spp. and Nominally Increases Cow Milk Tolerant Dose in Children with Cow's Milk Allergy – Preliminary Results

Published:2023-09-01 Issue:3 Volume:72 Page:299-306
ISSN:2544-4646
Container-title:Polish Journal of Microbiology
language:en
Short-container-title:

Author:

Kubota Shohei¹²,Sugiura Shiro¹,Takahashi Mayuko³^ORCID,Kadota Yoshihiro³,Takasato Yoshihiro¹,Matsui Teruaki¹,Kitamura Katsumasa¹,Tochio Takumi³⁴,Ito Komei¹⁵

Affiliation:

1. Aichi Children's Health and Medical Center , Obu-shi , Japan

2. Saiseikai Yokohamashi Tobu Hospital , Yokohama-shi , Japan

3. B Food Science Co., Ltd. , Chita-shi , Japan

4. Fujita Health University , Toyoake-shi , Japan

5. Nagoya University Graduate School of Medicine , Nagoya-shi , Japan

Abstract

Abstract A single-arm study was conducted with 10 children aged 2–12 years with severe cow's milk allergy (CMA) requiring complete allergen elimination. Subjects were administered kestose, a prebiotic, at 1 or 2 g/day for 12 weeks. Results of a subsequent oral food challenge (OFC) showed a statistically significant increase in the total dose of cow's milk ingestion (1.6 ml vs. 2.7 ml, p = 0.041). However, the overall evaluation of the OFC results, TS/Pro (total score of Anaphylaxis Scoring Aichi (ASCA)/cumulative dose of protein), showed no statistically significant improvement, although the values were nominally improved in seven out of 10 subjects. The 16S rDNA analysis of fecal samples collected from the subjects revealed a statistically significant increase in the proportion of Faecalibacterium spp. (3.8 % vs. 6.8%, p = 0.013), a type of intestinal bacterium that has been reported to be associated with food allergy. However, no statistically significant correlation was found between Faecalibacterium spp. abundance and the results of the OFC.

Publisher

Polish Society of Microbiologists

Subject

Microbiology (medical),Applied Microbiology and Biotechnology,General Medicine,Microbiology

Link

https://www.sciendo.com/pdf/10.33073/pjm-2023-030

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