The prevalence and factors associated with coronary heart disease in patients with gout

Abstract

Background. Gout is associated with increased risk of cardiovascular disease (CVD) morbidity and mortality. Therefore, an association between coronary heart disease (CHD) and gout deserves careful examination. The aim of this study was to determine the prevalence of CHD and factors associated with CHD in patients (pts) with gout. Methods. 286 male patients with gout were included; age – 51.2 [42.8; 59.4] years (ys), disease duration – 6.2 [3.8; 12.1] ys. All patients underwent standard clinical examination, screening traditional risk factors (TRF) of CVD. We estimated the adjusted odds ratio (OR) and 95% confidence interval (95% CI). Results. CHD was found in 111 out of the 286 pts (38.8%), MI had a history in 29.7%. Compared to individuals with CHD, participants without CHD were older (56.7 [52.1; 61.1] vs 46.2 [40.6; 53.4] ys), had longer duration of gout (9.3 [4.7; 15.1] vs 5.6 [3.3; 9.7] ys) (for all p<0.05). Abdominal obesity (OR=3.6; 95% CI: 1.2–10.9), family history of CHD (OR=2.2; 95% CI: 1.3–5.4), disease duration of gout more 10 ys (OR=2.8; 95% CI: 1.6–4.7), age of gout onset <35 ys (OR=5.5; 95% CI: 2.6–11.7), intraosseous tophi (OR=3.03; 95% CI: 1.8–5.01), nephrolithiasis (OR=1.7; 95% CI: 1.04–3.04), renal failure (OR=5.6; 95% CI: 2.7–11.4), serum total cholesterol (TC) (OR=1.6; 95% CI: 1.0–2.8), serum creatinine (OR=2.5; 95% CI: 1.2–5.1), increased the risk for CHD in patients with a gout. Conclusions. The prevalence of CHD was 38.8% among individuals with gout (third of patients had a history of MI 29.7%). Our study showed that both TRFs of CVD and the severity of gout and a history of renal failure contribute to the development of CHD in patients with gout.