Cultural Antigen in the Technology for Anti-Rabies Immunoglobulin Obtainment from Equine Blood Serum-Reference-Cited by-同舟云学术

Cultural Antigen in the Technology for Anti-Rabies Immunoglobulin Obtainment from Equine Blood Serum

Published:2012-08-20 Issue:4(114) Volume: Page:65-68
ISSN:0370-1069
Container-title:Problems of Particularly Dangerous Infections
language:
Short-container-title:Problemy Osobo Opasnykh Infektsii

Author:

Generalov S. V.¹,Abramova E. G.¹,Matveeva Zh. V.¹,Zhulidov I. M.¹,Lobovikova O. A.¹,Svintsov R. A.¹,Komissarov A. V.¹,Kireev M. N.¹,Nikiforov A. K.¹

Affiliation:

1. Russian Research Anti-Plague Institute “Microbe”

Abstract

week after immunization (specific activity is identified using neutralization reaction on the model of white mice and dot-blot immunoassay). This level of activity is sufficient for the fractioning of immune serum and extraction of anti-rabies immunoglobulin. Physicochemical and biological properties of the anti-rabies immunoglobulin, obtained with the help of cultural antigen technique, meet the requirements stated in the normative documentation on anti-rabies immunoglobulins extracted from equine blood serum. Specific activity level of experimental batches of anti-rabies immunoglobulin, obtained with the help of cultural technologies, corresponds to 242 and 214 IU/ml.

Publisher

Russian Research Anti-Plague Institute Microbe

Subject

Infectious Diseases,Microbiology (medical),Immunology,Microbiology,Epidemiology

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