Formation of Extracellular Traps - the Effective Mechanism of Organism Protection from Pathogen

Author:

Kravtsov A. L.1

Affiliation:

1. Russian Research Anti-Plague Institute Microbe

Abstract

Summarized and analyzed are modern literature data on capability of cells (neutrophils, eosinophils and labrocytes) realizing the mechanisms of innate immunity, to form extracellular traps that capture and kill pathogens by secretion of DNA and antibacterial granules content into extracellular space. The efficiency of capture and bacterial clearance is higher in extracellular traps than that in phagocytosis. The mechanism of extracellular bactericidal activity is supposed to play an important role in protection of organism from bacteria which are resistant to phagocytosis by leukocytes.

Publisher

Russian Research Anti-Plague Institute Microbe

Subject

Infectious Diseases,Microbiology (medical),Immunology,Microbiology,Epidemiology

Reference48 articles.

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4. Kravtsov A.L., Grebenyukova T.P., Taranenko T.M., Kuznetsov O.S., Chramchenkova T.A., Naumov A.V. [Flow cytofluorimetric monitoring for the development of neutrophil degranulation (azurophil) in the whole human blood as a response to endotoxin of Yersinia pestis]. Probl. Osobo Opasn. Infek. 1999; 79:81–9.

5. Kravtsov A.L., Shmel’kova T.P. [Secretory degranulation of neutro- phils as a trigger of inflammation and regulator of immune response: the role of serine leukocyte proteases and protease-activated receptors]. Epidemiol. Vaktsinoprofilakt. 2011; 1(56):79–87.

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