Affiliation:
1. SİVAS CUMHURİYET ÜNİVERSİTESİ
2. SİVAS BİLİM VE TEKNOLOJİ ÜNİVERSİTESİ
Abstract
Poor water solubility is the main drawback of phthalocyanine (Pc)-based second generation photosensitizing agents in photodynamic therapy (PDT). To resolve this, we proposed preparation of quaternized serotonin substituted zinc phthalocyanine (q-Ser-ZnPc) since the positive charge on quaternary amines could improve water-solubility and might limit self-interactions of hydrophobic aromatic surface of Pc in aqueous solutions. Briefly, serotonin substituted phthalonitrile was prepared by reaction of 4-nitrophthalonitrile with 5-hydroxytryptamine (Serotonin). Serotonin substituted zinc(II) phthalocyanine (Ser-ZnPc) was prepared by cyclotetramerization of serotonin substituted phthalonitrile. Then, q-Ser-ZnPc was prepared by the quaternization reaction of Ser-ZnPc. The synthesized compounds were characterized by 1H-NMR, UV-Vis, FT-IR, fluorescence, and elemental analysis. Importantly, unlike ZnPc, which is among most widely used second generation photosensitizing agents, we report that q-Ser-ZnPc is actually water-soluble. Besides, q-Ser-ZnPc also absorbs light in the wavelengths corresponding to the therapeutic window. What’s more, q-Ser-ZnPc exhibits a higher fluorescence quantum yield than that of ZnPc. Thus, the material might be useful particularly for image-guided PDT applications.
Reference40 articles.
1. [1] WHO (2022). “Cancer”. (Accessed: 10.03.2022) Available from:https://www.who.int/news-room/factsheets/detail/cancer#:~:text=Cancer%20is%20a%20leading%20cause,and%20rectum%20and%20prostate%20cancers.
2. [2] Borzecka W., Dominski A., Kowalczuk M., Recent Progress in Phthalocyanine-Polymeric Nanoparticle Delivery Systems for Cancer Photodynamic Therapy, Nanomaterials (Basel), 11(9) (2021) 2426-2458.
3. [3] Baykara O., Current Therapies and Latest Developments in Cancer Treatment, in Horizons in Cancer Research, Watanabe H. S., Editor., Nova Science Publishers, 57 (2015) 105-157.
4. [4] Monje M., Dietrich J., Cognitive side effects of cancer therapy demonstrate a functional role for adult neurogenesis, Behav. Brain. Res., 227(2) (2012) 376-379.
5. [5] De Annunzio S.R., Costa N.C.S., Mezzina R.D., Graminha M. A. S., Fontana C.R., Chlorin, Phthalocyanine, and Porphyrin Types Derivatives in Phototreatment of Cutaneous Manifestations: A Review, Int. J. Mol. Sci, 20(16) (2019) 3861-3882.
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