Synthesis, Cytotoxic Activity Evaluation and Molecular Docking Studies of Some Benzimidazole Derivatives-Reference-Cited by-同舟云学术

Synthesis, Cytotoxic Activity Evaluation and Molecular Docking Studies of Some Benzimidazole Derivatives

Published:2024-03-28 Issue:1 Volume:45 Page:80-87
ISSN:2587-2680
Container-title:Cumhuriyet Science Journal
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Author:

Kaya Aybüke Züleyha¹^ORCID,Osmaniye Derya¹^ORCID,Evren Asaf Evrim²^ORCID,Yurttaş Leyla¹^ORCID,Demirayak Şeref³^ORCID

Affiliation:

1. ANADOLU UNIVERSITY, FACULTY OF PHARMACY

2. BILECIK SEYH EDEBALI UNIVERSITY, HEALTH SERVICES VOCATIONAL SCHOOL

3. İSTANBUL SAĞLIK VE TEKNOLOJİ ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ

Abstract

In this study, the synthesis of 2-(2-acetyl-1H-benzimidazol-1-yl)-1-arylethanone (3a-3d) and 1-methyl-3-phenyl-benzo[4,5]imidazo[1,2-a]pyrazine derivatives (4a-4d) and to investigate their cytotoxic activity were aimed. APCI, IR, 1HNMR, and 13CNMR spectra were utilized to determine the structure of the synthesized compounds. The cytotoxic activity of selected compounds were detected in A549 (human lung carcinoma) and NIH3T3 (mouse embryonic fibroblasts) cell lines. Compounds 4c and 4d were found to be selectively cytotoxic against A549 and NIH3T3 cell lines. Molecular docking studies were performed using the data retrieved from the Protein Data Bank server (PDBID: 4QTX).

Publisher

Cumhuriyet University

Reference29 articles.

1. [1] M. Hou, H.C. Li, N. An, S.Y. Pang, W.G. Li, J. Tong, Synthesis, crystal structures and anticancer studies of Ni (Ⅱ), Co (Ⅲ) and Zn (Ⅱ) complexes based on 5-bromosalicylaldehyde- 2-(2-aminophenyl)benzimidazole Schiff base, J. Mol. Struct., 1294 (2023) 136500.

2. [2] The top 10 causes of death, (n.d.). https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death (accessed November 15, 2023).

3. [3] D. Nuha, A.E. Evren, Z.Ş. Çiyanci, H.E. Temel, G. Akalin Çiftçi, L. Yurttaş, Synthesis, density functional theory calculation, molecular docking studies, and evaluation of novel 5‐nitrothiophene derivatives for anticancer activity, Arch Pharm (Weinheim), 355 (2022).

4. [4] İ. Celik, G. Ayhan-Kılcıgil, B. Guven, Z. Kara, A.S. Gurkan-Alp, A. Karayel, A. Onay-Besikci, Design, synthesis and docking studies of benzimidazole derivatives as potential EGFR inhibitors, Eur. J. Med. Chem., 173 (2019) 240–249.

5. [5] A.E. Evren, L. Yurttaş, B. Eksellı, G. Akalın-Cıftcı, Novel Tri-substituted Thiazoles Bearing Piperazine Ring: Synthesis and Evaluation of their Anticancer Activity, Lett Drug Des Discov 16 (2019) 547-555. https://doi.org/10.2174/1570180815666180731122118.

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