Acetylcholinesterase Inhibitor Activity of Some 5-Nitrothiophene-Thiazole Derivatives-Reference-Cited by-同舟云学术

Acetylcholinesterase Inhibitor Activity of Some 5-Nitrothiophene-Thiazole Derivatives

Published:2022-12-27 Issue:4 Volume:43 Page:584-589
ISSN:2587-2680
Container-title:Cumhuriyet Science Journal
language:en
Short-container-title:CSJ

Author:

NUHA Demokrat¹,EVREN Asaf Evrim²^ORCID,ÇİYANCI Zennure Şevval²,TEMEL Halide Edip²,AKALIN ÇİFTÇİ Gülşen²,YURTTAŞ Leyla²^ORCID

Affiliation:

1. University for Business and Technology (UBT)

2. ANADOLU UNIVERSITY, FACULTY OF PHARMACY

Abstract

The potential anticholinesterase characteristics of some thiazole derivatives (2a–2j), including the 5-nitrothiophene moiety, were examined in this work. 1H-NMR, 13C-NMR, and HRMS spectral data were used to determine the structure of the compounds. Using a modified Ellman's spectrophotometric approach, each compound was tested for its ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. It was determined that the compounds exhibited inhibition of between 33.66–47.96 % against AChE and 13.03–63.29 % against BuChE at 80 µg/mL concentration.

Publisher

Cumhuriyet University

Subject

General Medicine

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