Affiliation:
1. SİVAS CUMHURİYET ÜNİVERSİTESİ
Abstract
This study is focused on developing a sensitive analytical method for Venlafaxine molecule which is antidepressant drug belonging to the serotonin-noradrenaline reuptake inhibitors (SNRI) group. With this study, a separation and preconcentration method based on fabric phase sorptive extraction(FPSE) method was developed for low levels of Venlafaxine in urine samples. Experimental variables such as pH, ionic strength, desorption solvent, and other parameters were studied and optimized step by step. The linearity of method under optimized conditions is in the range of 15.00-750.00 ng mL-1 while limit of detection is 4.28 ng mL-1. The relative standard deviation (RSD %) obtained from model solutions containing 300 ng mL-1 of Venlafaxine was lower than 3.1 % and pre-concentration factor was calculated as 62.50 for target molecule. In order to test accuracy of the method, recovery tests were carried out by means of spiked urine samples. As a result of recovery tests, quantative values were obtained in the range of 97.5-104.2 % successively.
Reference22 articles.
1. [1] M. Leblanc, L. Thibault, Effect of sibutramine on macronutrient selection in male and female rats, Physiol. Behav.,80 (2003) 243–252.
2. [2] A.R. Chaves, S.M. Silva, R.H.C. Queiroz, F.M. Lanças, M.E.C. Queiroz, Stir bar sorptive extraction and liquid chromatography with UV detection for determination of antidepressants in plasma samples, J. Chromatogr. B Anal. Technol. Biomed. Life Sci.,850 (2007) 295-302.
3. [3] N. Dilbaz, A.R. Özen, M. Ay, H. Güz, S. Karademir, Venlafaksin’in major depresyonda etkinlik ve emniyeti; ümitsizlik, intihar düşüncesi ve anksiyete üzerine etkisi: Bir açık çalışma, Psikofarmakoloji. Org., 9 (1999) 197–202.
4. [4] H. Juan, Z. Zhiling, L. Huande, Simultaneous determination of fluoxetine, citalopram, paroxetine, venlafaxine in plasma by high performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-MS/ESI), J. Chromatogr. B Anal. Technol. Biomed. Life Sci.,820 (2005) 33-39.
5. [5] S. Rani, A.K. Malik, R. Kaur, R. Kaur, A Review for the Analysis of Antidepressant, Antiepileptic and Quinolone Type Drugs in Pharmaceuticals and Environmental Samples, Crit. Rev. Anal. Chem.,46 (2016) 424-442.
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