Non-invasive measurement of oxygen metabolism. Part 1: Historical review and state of the art-Reference-Cited by-同舟云学术

Non-invasive measurement of oxygen metabolism. Part 1: Historical review and state of the art

Published:2023-02-08 Issue:4 Volume:27 Page:138-149
ISSN:2408-9516
Container-title:Medical Visualization
language:
Short-container-title:Medicinskaâ vizualizaciâ

Author:

Postnov A. A.¹^ORCID,Kalaeva D. B.²,Balakhonov A. B.³^ORCID,Pronin I. N.³^ORCID

Affiliation:

1. N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of the Russian Federation; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute); Research Institute of Technical Physics and Automation (“NIITFA”); P.N. Lebedev Physical Institute of the Russian Academy of Sciences

2. N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of the Russian Federation; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)

3. N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of the Russian Federation

Abstract

Oxygen metabolism is a key factor in the life of a living organism. The article is the first part of a review of methods for measuring oxygen metabolism.Purpose. The aim of this review is to present an insight into the evolution of methods for measuring oxygen metabolism in a way from global to local measurement of brain perfusion. The role of the 15O isotope as the “gold standard” for measuring oxygen metabolism using positron emission tomography (PET) is described. We also provide a case report of brain tumor perfusion measurements from our clinic.Materials and methods. More than 200 Pubmed publications were studied with the keywords “positron emission tomography + O-15”. Relevant publications that do not contain these keywords or contain them in a different wording were also analyzed. A clinical case of a brain tumor perfusion using CT perfusion, MR-ASL and PET with H215O is provided.Results. The evolution of methods for measuring perfusion, oxygen extraction, and oxygen metabolism, is described. More than 50 papers are cited depicting key advances in measurement technologies. Examples of the use of PET with H215O in fundamental research and clinical practice are given.Conclusion. The obvious value of oxygen-isotope PET data is combined with the invasiveness (in some cases), technical complexity and high cost of the procedure. The second part of the review will be devoted to alternative methods for measuring oxygen metabolism, which are developing in the 21st century and which are intended for wide clinical use.

Publisher

Vidar, Ltd.

Subject

Radiology, Nuclear Medicine and imaging,Radiological and Ultrasound Technology

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