UV–VISIBLE SPECTROPHOTOMETRIC DETERMINATION OF CHLORPROMAZINE HYDROCHLORIDE FROM PHARMACEUTICALS USING PLATINUM (IV) CHLORIDE

Author:

Nasr Maha Salah1,Al-Rufaie Mohauman Mohammad Majeed1

Affiliation:

1. Department of Chemistry, Faculty of Sciences, Kufa University. Najaf, Iraq

Abstract

The goal of this study is to develop a simple and precise spectrophotometric method for the quantitative determination of chlorpromazine hydrochloride (CPZ.HCL) by its reaction with platinum tetrachloride (PtC) in aqueous solutions (acidic medium) using UV-Vis spectrophotometry. Accordingly, a blue complex was formed having a characteristic band at 533 nm. To obtain high sensitivity and good stability, optimal reaction conditions were investigated, like the influence of pH, temperature, time, and the optimal concentration of platinum tetrachloride, as well as calibration curves were generated. Results indicated the possibility of using this method in estimating the drug above, as the calibration curve was subject to Beer's law for the range 5-75 µg/mL, and the molar absorptivity, Sandell's sensitivity, detection limit, and quantitative limit were 1563.32 L/mole·cm, 0.2272 µg/cm2 , 0.5102 and 1.7007 µg/mL respectively. The proposed procedure has also been successfully applied for CPZ·HCL quantification in the pharmaceutical form.

Publisher

Editura Universitatii Alexandru Ioan Cuza din Iasi

Subject

General Earth and Planetary Sciences,General Engineering,General Environmental Science

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3