Affiliation:
1. Department of Chemistry, Faculty of Science, University of Kufa, Najaf, Iraq
2. Department of Biology, Faculty of Science, University of Kufa, Najaf, Iraq
Abstract
Coupling reaction between the diazonium salt of 3-chloro-4-
fluoroaniline and 4-methyl imidazole used to create new Azoimidazole compound
(4MCFD). Solid complexes of this ligand and series of transition metal ion were
synthesized. The complexes and ligand were characterized by Mass Spectroscopy,
1H-NMR,13C-NMR, FT-IR, UV-Vis, Elemental Analysis, Molar Conductivity, and
their inhibition ability against E. coli, P. aeruginosa, K. pneumonia, and S. aureus
bacteria studied, according to the common chemical characterization methods. The
values of stability constants were also calculated and showed high level of
stability. All of the synthesized complexes have octahedral geometry with general
formula [M(4MCFD)2Cl2], (4MCFD) ligand behave as a bidentate. New ligand
and its complexes exhibited significant inhibitory efficacy against gram-negative
bacteria as compared to positive bacteria.
Publisher
Editura Universitatii Alexandru Ioan Cuza din Iasi