Author:
Gherghel Daniela,Mihai Cosmin-Teodor,Vochita Gabriela,Rosu Craita Maria
Abstract
This research is focused on cellular response to sodium metabisulphite (E223), sodium benzoate (E211), and sodium nitrite (E250) application on two normal mammalian cells, namely MCF-12A (ATCC CRL-3598) and Vero (ATCC CCL-81). The monitored parameters were cell viability (MTT assay), cell morphology (optical microscopy) and cell survival (clonogenic assay). The treatment was applied in doses of 12.5; 25; 50 and 100 µg/mL. According to all tests assessed, our results proved a dose-response relationship, the most sensibility presented the MCF-12A cell line.
Funder
Ministerul Cercetării şi Inovării
Publisher
Editura Universitatii Alexandru Ioan Cuza din Iasi
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