p-IgGen: A Paired Antibody Generative Language Model

Abstract

SummaryA key challenge in antibody drug discovery is designing novel sequences that are free from developability issues - such as aggregation, polyspecificity, poor expression, or low solubility. Here, we present p-IgGen, a protein language model for paired heavylight chain antibody generation. The model generates diverse, antibody-like sequences with pairing properties found in natural antibodies. We also create a finetuned version of p-IgGen that biases the model to generate antibodies with 3D biophysical properties that fall within distributions seen in clinical-stage therapeutic antibodies.