A Single Center Observational Study on 25-hydroxyvitamin D levels in Meniscus Injury Patients

Abstract

AbstractThere is limited research on the association between 25-hydroxyvitamin D levels and meniscus injury. This study investigated serum 25-hydroxyvitamin D (25-OHD) in meniscus injury patients and its association with other bioinorganic chemistry of micronutrients, and immune cells numbers from January 2023 to December 2023. A total of 198 participants were recruited between the age of 18 and 89 years. Participants with renal or liver failure, or any other chronic conditions, who were taking medications that might affect the metabolism of vitamin D, were not included in the study. In this study, we categorized serum 25(OH)D concentrations as follows: ≤30ngm/dl was categorized as insufficient, and >30ngm/dl was deemed sufficient. Among the 198 participants, 82% (n=162) were serum 25(OH)D deficient, while only 18% (n=36) participants were serum 25(OH)D sufficient. No significant difference observed in vitamin D deficiency among difference age, BMI, sex, blood pressure, inflammatory cell numbers, and other vitamins compared to the vitamin D sufficient group. Moreover, the serum 25(OH)D concentrations were negatively related to the severity of meniscus injury based on MRI examination. In conclusion, severe vitamin D deficiency is more common in patients with meniscus injury and may play a significant role in their prognosis.