Adults with Severe Acute Respiratory Illness in Glasgow, 2021-22: A Prospective Cohort Study

Author:

Ho AntoniaORCID,McInnes NeilORCID,Blunsum Andrew,Quinn JoannaORCID,Lynagh Daniel,Murphy Michael E,Gunson RoryORCID,MacConnachie Alisdair,Lowe David J

Abstract

AbstractObjectivesWe report the findings of a novel enhanced syndromic surveillance which characterised influenza- and SARS-CoV-2-associated severe acute respiratory illness (SARI) in the 2021/2022 winter season.MethodsProspective cohort study of adults admitted to the Queen Elizabeth University Hospital, Glasgow, with a severe acute respiratory illness. Patient demographics, clinical history, admission details, and outcome were recorded.ResultsBetween November 2021 and May 2022, 1,063 hospitalised SARI episodes in 1,037 adult patients were identified. Median age was 72.0 years and 44.5% were male. Most (82.6%) SARI cases had ≥1 co-morbidity; chronic lung disease (50.0%) and malignancy (22.5%) were the most frequently reported.Overall, 229 (22%) and 33 (3%) SARI episodes were SARS-CoV-2 and influenza A PCR positive, respectively. Overall, 74.7%, 6.5% and 43.0% SARI episodes received antibiotics, antivirals, and steroids, respectively (54.5, 11.0 and 51.3% among COVID-19 patients). 1.1% required mechanical ventilation and 7.8% died. Male sex, multimorbidity, frailty, respiratory rate >30, low GCS and chest X-ray consolidation were predictive of in-hospital mortality.ConclusionOur syndromic surveillance provided near real-time data on hospitalised SARI to clinicians and Public Health Scotland, and informed them of the evolving clinical epidemiology of SARS-CoV-2 and influenza as we transition from the pandemic phase.

Publisher

Cold Spring Harbor Laboratory

Reference27 articles.

1. Public Health England. Sources of UK flu data: influenza surveillance in the UK. Seasonal influenza: guidance, data and analysis: Public Health England, 2014.

2. Public Health England. Surveillance of influenza and other seasonal respiratory viruses in the UK: Winter 2020 to 2021: Public Health England, 2021:1–51.

3. World Health Organization. End-to-end integration of SARS-CoV-2 and influenza sentinel surveillance: revised interim guidance, 2022.

4. European Centre for Disease Prevention and Control. Operational considerations for respiratory virus surveillance in Europe 2022 [Available from: https://www.ecdc.europa.eu/en/publications-data/operational-considerations-respiratory-virus-surveillance-europe accessed 26 May 2024.

5. Griffiths E , Greci C , Kotrotsios Y , et al. Handbook on Statistical Disclosure Control for Outputs. Version 1.0. In: Group SDAPW, ed., 2019:1–92.

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