Diminished social memory and hippocampal correlates of social interactions in chronic social defeat stress susceptibility

Abstract

AbstractBackgroundThe susceptibility to chronic stress has been associated with depression, a mood disorder which highly implicates the hippocampus. Hippocampal contribution to stress susceptibility has been supported by findings in mice following chronic social defeat stress (CSDS). However, little is known of the role of hippocampal activity in determining the development of stress susceptibility.MethodsWe used the UCLA miniscope to longitudinally measure the activity of dorsal CA1 hippocampal neurons across CSDS. Apart from examining the representation of social information by these neurons, we also compared social memory in mice that were susceptible or resilient to CSDS.ResultsWe observed more stable dCA1 correlates of social interaction and social memory in CSDS resilience. Such changes were absent in CSDS susceptible mice and accompanied by greater social memory impairments.ConclusionsCSDS susceptibility may be supported by hippocampal social cognitive processes, reflected in diminished hippocampal representations of social information and a greater impairment in social memory.