Revisiting equivalent optical properties for cerebrospinal fluid to improve diffusion-based modeling accuracy in the brain

Abstract

AbstractSignificanceThe diffusion approximation (DA) is used in functional near-infrared spectroscopy (fNIRS) studies despite its known limitations due to the presence of cerebrospinal fluid (CSF). Nearly all of these studies rely on a set of empirical CSF optical properties, recommended by a previous simulation study, that were not selected for the purpose of minimizing DA modeling errors.AimWe aim to directly quantify the accuracy of DA solutions in brain models by comparing those with the goldstandard solutions produced by the mesh-based Monte Carlo (MMC), based on which we derive updated recommendations.ApproachFor both a 5-layer head and Colin27 atlas models, we obtain DA solutions by independently sweeping the CSF absorption (μa) and reduced scatteringcoefficients. Using an MMC solution with literature CSF optical properties as reference, we compute the errors for surface fluence, total brain sensitivity and brain energy-deposition, and identify the optimized settings where the such error is minimized.ResultsOur results suggest that previously recommended CSF properties can cause significant errors (8.7% to 52%) in multiple tested metrics. By simultaneously sweepingμaand, we can identify infinite numbers of solutions that can exactly match DA with MMC solutions for any single tested metric. Furthermore, it is also possible to simultaneously minimize multiple metrics at multiple source/detector separations, leading to our new recommendation of settingwhile maintaining physiologicalμafor CSF in DA simulations.ConclusionOur new recommendation of CSF equivalent optical properties can greatly reduce the model mismatches between DA and MMC solutions at multiple metrics without sacrificing computational speed. We also show that it is possible to eliminate such a mismatch for a single or a pair of metrics of interest.