Comment to: “Topology of molecular deformations induces triphasic catch bonding in selectin–ligand bonds”

Abstract

We contradict diverse mathematical claims of a paper by Casey O. Barkan and Robijn F. Bruinsma in PNAS 2024, 121, No. 6, e2315866121, former BioRxiv preprint from Sept.12,2023. It deals with the physical mechanisms of protein-ligand catch bonding for the family of selectin proteins. Selectins exhibit slip, catch–slip, and slip–catch–slip bonding.