Author:
Salimi Morteza,Nazari Milad,Mishler Jonathan,Mishra Jyoti,Ramanathan Dhakshin S
Abstract
AbstractTheta burst stimulation (TBS), an FDA-cleared treatment for depression, is hypothesized to modulate excitability in the prefrontal cortex, though this has not definitively been shown in vivo. We performed calcium imaging on glutamatergic neurons in awake rodents to understand the effects of theta burst stimulation at a cellular level. Our findings provide the first direct evidence that TBS bidirectionally modulates glutamatergic activity when delivered in vivo and directly links calcium activity changes during stimulation with post-stimulation plasticity.
Publisher
Cold Spring Harbor Laboratory