Author:
Shah Zalak,Naung Myo T.,Moser Kara A.,Adams Matthew,Buchwald Andrea G.,Dwivedi Ankit,Ouattara Amed,Seydel Karl B,Mathanga Don P.,Barry Alyssa E.,Serre David,Laufer Miriam K.,Silva Joana C.,Takala-Harrison Shannon
Abstract
AbstractIndividuals acquire immunity to clinical malaria after repeated Plasmodium falciparum infections. This immunity to disease is thought to reflect the acquisition of a repertoire of responses to multiple alleles in diverse parasite antigens. In previous studies, we identified polymorphic sites within individual antigens that are associated with parasite immune evasion by examining antigen allele dynamics in individuals followed longitudinally. Here we expand this approach by analyzing genome-wide polymorphisms using whole genome sequence data from 140 parasite isolates representing malaria cases from a longitudinal study in Malawi and identify 25 genes that encode likely targets of naturally acquired immunity and that should be further characterized for their potential as vaccine candidates.
Publisher
Cold Spring Harbor Laboratory
Cited by
1 articles.
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