Author:
Selvakumari M.,AnandKarthikeyan D.,Ramakrishnan R.,George Melvin
Abstract
AbstractObjectivesThere is an increasing evidence of immune mediated mechanism in the etiopathogenesis of Otitis Media – ‘middle ear inflammation’. The aim of the present study was to determine the expression of important circulatoryregulators of‘immunotolerance’as biomarkers.Materials and MethodsIn this cross sectional study, a total of 44 OM patients and 37 controls were included. Blood plasma level of HB-EGF, IL-10, TNF-α, IFN-γ, PD-L1 and VEGF-A were quantified using Human Magnetic Luminex assay.ResultsThe study showed statistical significant differences in the levels of VEGF-A between OM patients with and without tympanic membrane perforations (p<0.05). Moreover, we found comparatively higher level of PD-L1 in OM patients than controls. However, the level of growth factor HB-EGF, is significantly higher in controls than the cases (p<0.05). There was also a correlation between the levels of HB-EGF and VEGF-A and the severity of the disease condition.ConclusionsRole of inflammatory mediators and cytokines like PD-L1, IFNγ, TNFα and IL-10in OM patients as a biomarkers are very minimal. VEFG-A have a significant role in the pathogenesis of OM.Further studies are required for better understanding of the role of these immunosuppressive mediators in the eitopathogenesis of OM.
Publisher
Cold Spring Harbor Laboratory
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