Author:
Chen Fang,Liu Bin,Chen Meirong,Jiang Zefei,Zhou Zhiliang,Wu Ping,Zhang Meng,Jin Huan,Li Linsen,Lu Liuyan,Wang Qi,Shang Huan,Xie Bing,Liu Lei,Lin Xia,Chen Weiyue,Xu Jianfeng,Sun Ruitao,Wang Guangming,Zheng Jiao,Qi Jifang,Yang Bo,Chen Dexia,Zeng Lidong,Li Gailing,Li Yan,Lv Hui,Zhao Nannan,Zhou Bo,Wang Wen,Cai Jinsen,Liu Siyu,Luo Weiwei,Zhang Juan,Zhang Yanhua,Lu Yongyi,Fan Jicai,Dan Haitao,He Xuesen,Liu Lichun,Feng Yan,Chen Jianglin,Huang Wei,Sun Lei,Yan Qin
Abstract
AbstractWith the rapid development of precision medicine industry, DNA sequencing becomes increasingly important as a research and diagnosis tool. For clinical applications, medical professionals require a platform which is fast, easy to use, and presents clear information relevant to definitive diagnosis. We have developed a single molecule desktop sequencing platform, GenoCare™ 1600. Fast library preparation (without amplification) and simple instrument operation make it friendlier for clinical use. Here we presented sequencing data of E. coli sample from GenoCare™ 1600 with consensus accuracy reaches 99.99%. We also demonstrated sequencing of microbial mixtures and COVID-19 samples from throat swabs. Our data show accurate quantitation of microbial, sensitive identification of SARS-CoV-2 virus and detection of variants confirmed by Sanger sequencing.
Publisher
Cold Spring Harbor Laboratory