Episodic long-term memory formation during slow-wave sleep

Abstract

SummaryWe are unresponsive during slow-wave sleep but continue monitoring external events for survival. Our brain wakens us when danger is imminent. If events are non-threatening, our brain might store them for later consideration to improve decision-making. To test this hypothesis, we examined whether simultaneously sleep-played foreign words and translation words are encoded/stored and which neural-electrical events facilitate encoding/storage. A closed-loop algorithm targeted word pairs to slow-wave peaks or troughs. Retrieval tests were given 12 and 36 hours later. These tests required decisions regarding the semantic category of previously sleep-played foreign words. The sleep-played vocabulary influenced awake decision-making 36 hours later, if targeted to troughs. The words’ linguistic processing raised neural complexity. The words’ semantic-associative encoding was supported by increased theta power during the ensuing peak. Fast-spindle power ramped up during a second peak likely aiding consolidation. Hence, new vocabulary played during slow-wave sleep was stored and influenced decision-making days later.