Improving cell-type identification with Gaussian noise-augmented single-cell RNA-seq contrastive learning

Abstract

ABSTRACTCell-type identification is an important task for single-cell RNA-seq (scRNA-seq) data analysis. In this work, we proposed a novel Gaussian noise augmented scRNA-seq contrastive learning framework (GsRCL) to learn a type of discriminative feature representations for cell-type prediction tasks. The experimental results suggest that the feature representations learned by GsRCL successfully improved the accuracy of cell-type prediction using scRNA-seq expression profiles.