Supplementation of AQUATURM® (Water soluble turmeric extract) prior to and following heavy eccentric exercise alleviates symptoms of Delayed onset muscle soreness (DOMS)

Abstract

AbstractBackgroundCurcumin, the most active component in turmeric helps attenuate DOMS.ObjectivesA clinical study was conducted to evaluate efficacy and safety of AQUATURM® in subjects with Delayed Onset Muscle Soreness (DOMS).MethodsTwenty healthy men in each of the two subsets completed the study. Subjects were assigned as per a computer-generated randomization list. In subset-I, subjects were asked to take given product in a dose of 1 capsule (250 mg) for 2 days. In subset-II, subjects were asked to take given product in a dose of 1 capsule (250mg) for 5 days. In subset-I, eccentric exercise was performed at hour 6. In subset-II eccentric exercise was performed at day 2.5. The outcome measures were muscle pain, tenderness, swelling, jump performance, muscle inflammatory markers, rescue medication and adverse events. These outcome measures were evaluated at 0 hour, at 6 hours (immediately after exercise), at 24 hours and at 48 hours in subset-I, and at day 1, day 2.5 baseline (immediately after exercise), at 24 hours from baseline and at 48 hours from baseline in subset-II.ResultsA significant reduction in muscle pain, tenderness and swelling post eccentric exercise was observed in AQUATURM® Capsule group compared to placebo group in both the subsets of the study. Additionally, when compared to the placebo group, the AQUATURM® group showed a statistically significant increase in post exercise average single-leg vertical squat jump. AQUATURM® Capsule was well tolerated by the subjects.ConclusionSupplementation of AQUATURM® Capsule prior to and following heavy eccentric exercise in healthy men resulted in relieving muscle pain, tenderness and swelling from DOMS.