Schwann cells promote sensory neuron excitability during development

Author:

Kantarci HusniyeORCID,Elvira Pablo D.,Thottumkara Arun P.,Iyer Manasi,Donovan Lauren J.,Dugan Micaela Quinn,Ambiel Nicholas,O’Connell Emma M.,Granados Alejandro,Zeng Hong,Saw Nay L.,Lutz Amanda Brosius,Sloan Steven A.,Gray Erin E.,Tran Khanh V.,Vichare Aditi,Yeh Ashley K.,Münch Alexandra E.,Huber Max,Agrawal Aditi,Morri Maurizio,Shamloo Mehrdad,Anderson Thomas Anthony,Tawfik Vivianne L.,Du Bois J.,Bradley Zuchero J.

Abstract

SUMMARYExcitability—the ability to fire action potentials—is a signature feature of neurons. How neurons become excitable during development, and whether excitability is an intrinsic property of neurons or requires signaling from glial cells, remain unclear. Here we demonstrate that Schwann cells, the most abundant glia in the peripheral nervous system, promote somatosensory neuron excitability during development. We find that Schwann cells secrete prostaglandin E2, which is necessary and sufficient to induce developing somatosensory neurons to express normal levels of voltage-gated sodium channels and fire action potential trains. Inactivating this signaling pathway specifically in Schwann cells selectively impairs the maturation of nociceptor and proprioceptor somatosensory neuron subtypes, leading to corresponding sensory defects in thermoception, inflammatory pain, and proprioception. Our studies thus reveal a cell non-autonomous mechanism by which glia regulate neuronal excitability to enable the development of normal sensory functions.

Publisher

Cold Spring Harbor Laboratory

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