The striatum drives the ergogenic effects of caffeine

Author:

de Bem Alves Ana CristinaORCID,Speck Ana ElisaORCID,Resende Farias HémelinORCID,Martins Leo MeiraORCID,dos Santos Naiara SouzaORCID,Pannata GabrielaORCID,Tavares Ana PaulaORCID,de Oliveira JadeORCID,Tomé Ângelo R.ORCID,Cunha Rodrigo A.ORCID,Aguiar Aderbal SORCID

Abstract

AbstractCaffeine is one of the main ergogenic resources used in exercise and sports. Previously, we reported the ergogenic mechanism of caffeine through neuronal A2AR antagonism in the central nervous system [1]. We now demonstrate that the striatum rules the ergogenic effects of caffeine through neuroplasticity changes. Thirty-four Swiss (8-10 weeks, 47 ± 1.5 g) and twenty-four C57BL/6J (8-10 weeks, 23.9 ± 0.4 g) adult male mice were studied behaviorly and electrophysiologically using caffeine and energy metabolism was studied in SH-SY5Y cells. Systemic (15 mg/kg, i.p.) or striatal (bilateral, 15 μg) caffeine was psychostimulant in the open field (p< 0.05) and increased grip efficiency (p< 0.05). Caffeine also shifted long-term depression (LTD) to potentiation (LTP) in striatal slices and increased the mitochondrial mass (p< 0.05) and membrane potential (p< 0.05) in SH-SY5Y dopaminergic cells. Our results demonstrate the role of the striatum in the ergogenic effects of caffeine, with changes in neuroplasticity and mitochondrial metabolism.

Publisher

Cold Spring Harbor Laboratory

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