Abstract
AbstractBackgroundRoss River virus (RRV) is Australia’s most important arbovirus given its annual burden of disease and the relatively large number of Australians at risk for infection. This mosquito-borne arbovirus is also a zoonosis, making its epidemiology and infection ecology complex and cryptic. Our grasp of enzootic, epizootic, and zoonotic RRV transmission dynamics is imprecise largely due to a poor understanding of the role of wild mammalian hosts in the RRV system.MethodsThe current study applied a piecewise structural equation model (PSEM) toward an interspecific comparison of sylvatic Australian mammals to characterize the ecological and life history profile of species with a history of RRV infection relative to those species with no such history among all wild mammalian species surveyed for RRV infection. The effects of species traits were assessed through multiple causal pathways within the PSEM framework.ResultsSylvatic mammalian species with a history of RRV infection tended to express dietary specialization and smaller population density. These species were also characterized by a longer gestation length.ConclusionsThis study provides the first interspecific comparison of wild mammals for RRV infection and identifies some potential targets for future wildlife surveys into the infection ecology of this important arbovirus. An applied RRV macroecology may prove invaluable to the epidemiological modeling of RRV epidemics across diverse sylvatic landscapes, as well as to the development of human and animal health surveillance systems.
Publisher
Cold Spring Harbor Laboratory
Reference56 articles.
1. Knope KE , Kurucz N , Doggett SL , et al (2016) Arboviral diseases and malaria in Australia, 2012–13: annual report of the national arbovirus and malaria advisory committee
2. NNDSS 2010 Annual Report Writing Group (2012) Australia’s notifiable diseases status, 2010: annual report of the national notifiable diseases surveillance system - results: zoonoses. Commun Dis Intell 36:
3. Antibiotic Modulation of Capsular Exopolysaccharide and Virulence in Acinetobacter baumannii
4. Hydrological features and the ecological niches of mammalian hosts delineate elevated risk for Ross River virus epidemics in anthropogenic landscapes in Australia
5. The non-human reservoirs of Ross River virus: a systematic review of the evidence