The plant calcium-dependent protein kinase CPK3 phosphorylates REM1.3 to restrict viral infection

Author:

Perraki Artemis,Gronnier JulienORCID,Gouguet Paul,Boudsocq MarieORCID,Deroubaix Anne-Flore,Simon Vincent,German-Retana Sylvie,Zipfel CyrilORCID,Bayer EmmanuelleORCID,Mongrand SébastienORCID,Germain Véronique

Abstract

AbstractPlants respond to pathogens through dynamic regulation of plasma membrane-bound signaling pathways. To date, how the plant plasma membrane is involved in responses to viruses is mostly unknown. Here, we show that plant cells sense the Potato virus X (PVX) COAT PROTEIN and TRIPLE GENE BLOCK 1 proteins and subsequently trigger the activation of a membrane-bound calcium-dependent kinase. We show that the Arabidopsis thaliana CALCIUM-DEPENDENT PROTEIN KINASE 3-interacts with group 1 REMORINs in vivo, phosphorylates the intrinsically disordered N-terminal domain of the Group 1 REMORIN REM1.3, and restricts PVX cell-to-cell movement. REM1.3-s phospho-status defines its plasma membrane nanodomain organization and is crucial for REM1.3-dependent restriction of PVX cell-to-cell movement by regulation of callose deposition at plasmodesmata. This study unveils plasma membrane nanodomain-associated molecular events underlying the plant immune response to viruses.

Publisher

Cold Spring Harbor Laboratory

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