House modifications using insecticide treated screening of eave and window as vector control tool: evidence from a semi-field system in Tanzania and simulated epidemiological impact

Author:

Odufuwa Olukayode G.ORCID,Sheppard Richard J.ORCID,Ngonyani Safina,Mpelepele Ahmadi Bakari,Kobe Dickson,Njohole Agathus,Moore Jason,Lusoli Jastin Lusoli,Muganga Joseph B.,Bosselmann Rune,Skovmand OleORCID,Mboma Zawadi MageniORCID,Mbuba EmmanuelORCID,Philipo Rose,Stevenson Jenny,Sherrard-Smith EllieORCID,Bradley JohnORCID,Moore Sarah JaneORCID

Abstract

AbstractBackgroundDespite extensive use of available vector control tools, the burden of malaria and dengue continues to increase throughout sub-Saharan Africa. Gaps in house structures, most especially in eaves and windows, allow vector entry and facilitate indoor vector biting and disease burden. Simple house modification tools that target these structures therefore have the potential to reduce human exposure to bites in the home. This study assessed the performance of Insecticide Treated Screening (ITS) comprising Eave Nets and Window Screens (ITENs & ITWS), incorporated with deltamethrin and piperonyl-butoxide (PBO) in Tanzania.MethodA randomised Latin square (4 X 4) was conducted in four experimental huts built in a semi-field system (SFS). Each hut within each of the chambers of the SFS was covered with a large netting cage to allow recapture of mosquitoes inside and outside of the huts. Four treatment arms were evaluated: 1) new ITS; 2) 12-months naturally-aged ITS; 3) estimated 12 months field-used Olyset® Plus ITNs (Standard-of-Care in Tanzania), and; 4) no treatment. The study was performed for 32 nights using a minimum of 30 mosquitoes per strain per night, that is, a total of 120 (4 x 30) mosquitoes per hut per night. Four laboratory-reared strains were used: transmitters of malaria (Anopheles arabiensisandAn. funestus) and dengue infection (Aedes aegypti) and those known for nuisance biting (Culex quinquefasciatus). Recaptured mosquitoes were assessed for mortality at 72 hours (M72), blood feeding and hut entry endpoints. A simulation exercise with a modified mechanistic model trackingPlasmodium falciparummalaria was used to illustrate the potential epidemiological impact from these products.ResultsNew ITS induced higher M72 than field-used ITNs against all mosquito species tested [OR: 2.25 (95%CI: 1.65-3.06), p<0.0001], while M72 was similar between aged ITS and field-used ITNs [OR: 0.80 (95%CI: 0.59-1.08), p=0.141]. Both new, and aged ITS reduced more mosquito blood feeding and hut entry than field-used ITNs for all mosquito species tested (p<0.0001). Transmission model estimates indicate epidemiological impacts of ITS may supersede those of ITNs at the population level. The model results indicate that the potency of these impacts depends on assumed intervention percentage cover, durability and mosquito bionomics.ConclusionsITS is an efficacious tool for controlling vectors transmitting malaria, and dengue, and those known for nuisance biting in a semi-field setting. Given the intervention’s simplicity, it should be considered as an additional (or stand-alone) tool alongside behavioural change educational efforts to encourage the repurposing of old ITNs for house screening.

Publisher

Cold Spring Harbor Laboratory

Reference95 articles.

1. The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015

2. World Health Organization. World Malaria report. WHO publications: 2023.

3. World Health Organization. WHO Global Malaria Programme: Position Statement on ITNs http://www.who.int/malaria/publications/atoz/itnspospaperfinal.pdf. Geneva: World Health Organization, 2007.

4. World Health Organization. Operational manual on indoor residual spraying: control of vectors of malaria, Aedes-borne diseases, Chagas disease, leishmaniases and lymphatic filariasis. Geneva: World Health Organization, 2023.

5. Evaluation of Commercial Agrochemicals as New Tools for Malaria Vector Control

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3