Association of aortic clamping time with systemic immune inflammation and systemic inflammatory response indexes in isolated coronary bypass surgery

Abstract

ObjectiveAortic clamping time during cardiopulmonary bypass (CPB) has been associated with inflammatory processes such as systemic inflammatory response syndrome. In this study, we evaluated the association of CPB and aortic cross-clamping (ACC) times with systemic inflammatory response index (SIRI) and systemic immune inflammation index (SIII) in isolated coronary artery bypass surgery (CABG).Methods96 patients who underwent isolated CABG at a single center between 2021 and 2023 were retrospectively analyzed. Patients were divided into below median aortic clamp time (group I; n=56) and above median aortic clamp time (group II; n=42) according to median aortic clamp time (66.2 minutes). Demographic data, preoperative and postoperative laboratory parameters were recorded. SIRI and SIII values were calculated.ResultsBaseline demographic data were similar between the groups. The duration of CPB and aortic clamping was significantly longer in group II (p<0.001). SIII and SIRI values were significantly increased in both groups in the postoperative period. However, there was no correlation between increased CPB and ACC durations and SIII and SIRI. However, no significant difference was observed in postoperative SIII and SIRI values between the groups. A weak correlation was found between SIII index and postoperative albumin levels.ConclusionsThere is no significant relationship between aortic clamping time and inflammatory indices in patients undergoing isolated CABG surgery. Increasing the duration of surgery does not affect the change in SIRI and SIII values.