Sexually dimorphic control of aggression by androgen signaling in a cichlid

Abstract

AbstractInnate social behaviors like aggression are modulated by sex steroid hormones such as androgens and estrogens. However, we know little about how the same hormone regulates similar behaviors in both sexes. We investigated the role of androgenic signaling in the regulation of aggression inAstatotilapia burtoni, a social fish in which males and females perform similar aggressive behaviors. We used ARα knockout (KO) animals for this study, which was recently shown to be required for male-typical aggression and mating. Surprisingly, ARα KO females did not show deficits in aggression. We also determined that females lacking the other AR, ARβ showed normal levels of aggression. Blocking both ARs pharmacologically confirmed that neither AR is necessary for aggression in females. However, ARα KO males showed clear deficits in attacks. Thus, inA. burtonithere appears to be a sexual dimorphism in the role of ARα in the control of aggression.