Abstract
AbstractObjectiveThis retroactive meta-analysis assesses the relationship between Mycobacterium avium subspecies paratuberculosis (MAP) and Crohn’s Disease (CD).MethodsA meta-analysis of PCR– and culture–based studies was conducted to determine if there is a relationship between MAP and Crohn’s Disease. The chi-squared test of independence was also conducted to determine if MAP infection and Crohn’s disease onset are independent events.ResultsThe studies analyzed were able to provide evidence that Mycobacterium avium subspecies paratuberculosis is highly associated with Crohn’s disease. It is also shown that, regardless of detection method, MAP can effectively be detected in Crohn’s patients.ConclusionMAP is strongly connected with Crohn’s Disease.SummaryThis paper examines the incidence of MAP in the tissue of Crohn’s disease patients. We found evidence to support MAP being strongly associated with Crohn’s disease.
Publisher
Cold Spring Harbor Laboratory
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