Author:
Chodrow Philip,Su Jessica,Lee Daniel,Ahmed Tahmid,He Neil,Ruben De Man,Tiwari Ankur,Mannherz William,Citi Luca,DiCorpo Daniel,Michaelson James Selib
Abstract
AbstractOur lives begin with 1 cell, then 2, then 4, then the trillion cell adult, comprised of cell lineages, tissues, organs. How does this occur? Examination in numbers of cells, N, Cellular Phylodynamics, revealed two previously unappreciated processes: UNI-GROWTH, the slowing of growth that occurs as we become larger, caused by fewer cells dividing, captured by the Universal Mitotic Fraction and Universal Growth Equations, with accuracy confirmed for 13 species, including nematodes, mollusks, and vertebrates; and ALLO-GROWTH, the creation of body parts from Founder Cells, captured by the Cellular Allometric Growth Equation, which describes mitotic expansion by Cell-Heritable change in the Cell Cycle Time. These equations can generate cell lineage approximations, bringing the power of coalescent theory to developmental biology.
Publisher
Cold Spring Harbor Laboratory
Cited by
3 articles.
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