Abstract
AbstractBackgroundDNA methylation (DNAm) may play an important role in birth outcomes.Material and MethodsGenome wide DNAm was analysed in peripheral blood DNA of women at multiple time points during gestation. A novel empirical method was used to identify CpG sites with high temporal variance in methylation associating with preterm birth.ResultsHigh variability at 1296 CpG sites from the promoter regions of 1197 genes significantly associated with PTB. These genes belonged to pathways involved in signalling by platelet derived growth factor, platelet homeostasis, collagen degradation, extracellular matrix and circadian clock.ConclusionsThe findings provide novel information which might help in development of predictive biomarkers of preterm birth outcome.
Publisher
Cold Spring Harbor Laboratory
Reference65 articles.
1. Collins JL , Lehnherr J , Posner SF , Toomey KE . Ties that bind: Maternal and child health and chronic disease prevention at the centers for disease control and prevention. Preventing chronic disease 6(1) (2009).
2. Butler AS , Behrman RE , others. Preterm birth: Causes, consequences, and prevention. (Editions). National Academies Press (2007).
3. Preterm birth: A continuing challenge;The Journal of perinatal education,2002
4. Sharma P , Khan S , Ghule M et al. Rationale & design of the PROMISES study: a prospective assessment and validation study of salivary progesterone as a test for preterm birth in pregnant women from rural India. Reprod. Health 15 (2018).
5. Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis;Lancet Global Health,2019