Author:
May Danielle G.,Martin-Sancho Laura,Anschau Valesca,Liu Sophie,Chrisopulos Rachel J.,Scott Kelsey L.,Halfmann Charles T.,Peña Ramon Díaz,Pratt Dexter,Campos Alexandre R.,Roux Kyle J.
Abstract
AbstractThe novel coronavirus SARS-CoV-2 is responsible for the ongoing COVID-19 pandemic and has caused a major health and economic burden worldwide. Understanding how SARS-CoV-2 viral proteins behave in host cells can reveal underlying mechanisms of pathogenesis and assist in development of antiviral therapies. Here we use BioID to map the SARS-CoV-2 virus-host interactome using human lung cancer derived A549 cells expressing individual SARS-CoV-2 viral proteins. Functional enrichment analyses revealed previously reported and unreported cellular pathways that are in association with SARS-CoV-2 proteins. We have also established a website to host the proteomic data to allow for public access and continued analysis of host-viral protein associations and whole-cell proteomes of cells expressing the viral-BioID fusion proteins. Collectively, these studies provide a valuable resource to potentially uncover novel SARS-CoV-2 biology and inform development of antivirals.
Publisher
Cold Spring Harbor Laboratory
Cited by
7 articles.
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