Author:
Cedernaes Jonathan,Waldeck Nathan,Bass Joseph
Abstract
Circadian rhythms are driven by a transcription–translation feedback loop that separates anabolic and catabolic processes across the Earth's 24-h light–dark cycle. Central pacemaker neurons that perceive light entrain a distributed clock network and are closely juxtaposed with hypothalamic neurons involved in regulation of sleep/wake and fast/feeding states. Gaps remain in identifying how pacemaker and extrapacemaker neurons communicate with energy-sensing neurons and the distinct role of circuit interactions versus transcriptionally driven cell-autonomous clocks in the timing of organismal bioenergetics. In this review, we discuss the reciprocal relationship through which the central clock drives appetitive behavior and metabolic homeostasis and the pathways through which nutrient state and sleep/wake behavior affect central clock function.
Funder
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute on Aging
Chicago Biomedical Consortium
University of Chicago Diabetes Research and Training Center
Swedish Society for Medical Research
Swedish Brain Research Foundation
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Cited by
36 articles.
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