Updating the sulcal landscape of the human lateral parieto-occipital junction provides anatomical, functional, and cognitive insights

Author:

Willbrand Ethan H.ORCID,Tsai Yi-Heng,Gagnant Thomas,Weiner Kevin S.ORCID

Abstract

AbstractRecent work has uncovered relationships between evolutionarily new small and shallow cerebral indentations, or sulci, and human behavior. Yet, this relationship remains unexplored in the lateral parietal cortex (LPC) and the lateral parieto-occipital junction (LPOJ). After defining thousands of sulci in a young adult cohort, we uncovered four previously unidentified small and shallow LPC/LOPJ sulci—one of which (ventral supralateral occipital sulcus, slocs-v) is present in nearly every hemisphere, and is morphologically, architecturally, and functionally dissociable from neighboring regions. A data-driven, model-based approach relating sulcal depth to behavior revealed that the morphology of only a subset of LPC/LPOJ sulci, including the slocs-v, is related to performance on a spatial orientation, but not a relational reasoning task. Our findings build on classic neuroanatomical theories and identify new neuroanatomical targets for future “precision imaging” studies exploring the relationship among brain structure, brain function, and cognitive abilities in individual participants.

Publisher

Cold Spring Harbor Laboratory

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