Effects of vitamin D deficiency on blood lipids and bone metabolism: a large cross-sectional study

Abstract

AbstractPurposeTo investigate the relationship between serum HDL-C and spinal bone mineral density (BMD) under different serum 25-hydroxyvitamin D (25 (OH) D) levels in adults over 40 years old and to explore its mechanism.MethodsParticipants over the age of 40 with data on HDL-C, 25 (OH) D, spinal BMD, and other variables in NHANES 2007–2010 were included in the final analysis. A weighted multiple linear regression model was used to evaluate the association between serum HDL-C and spinal BMD in different gender, ages and serum 25 (OH) D levels.ResultsA total of 3599 subjects aged ≥ 40 years old were included in this study. Univariate analysis of the complete correction model showed a negative correlation between serum HDL-C and spinal BMD. In the two subgroups of serum 25(OH)D, we found that the higher the serum HDL-C in the female with serum 25 (OH) D < 75nmol/L aged 40-59 years old, the lower the total spinal BMD, and a similar relationship was found in the lumbar spine (L1-L4). However, no similar relationship was found in all populations with serum 25 (OH) D ≥ 75nmol/L and males with serum 25 (OH) D < 75nmol/L.ConclusionAmong Americans over the age of 40, the increase of serum HDL-C is related to decreased BMD of spine only in women aged 40-59 years with vitamin D insufficiency or deficiency.Author summaryWe performed a cross-sectional study using the National Health Examination and Nutrition Survey (NHANES) data. We found that increased serum high-density lipoprotein cholesterol (HDL-C) during vitamin D deficiency is a potential risk factor for osteopenia or osteoporosis in middle-aged and elderly American women.