Preterm infants show an atypical processing of the mother’s voice

Abstract

AbstractTo understand the consequences of prematurity on language perception it is fundamental to determine how atypical early sensory experience affects brain development. To date the neural oscillatory correlates in the time-frequency domain of voice processing as a function of atypical early sensory experience, as after premature birth, remain elusive. At term equivalent age, ten preterm and ten full-term newborns underwent high-density EEG recordings during mother or stranger speech presentation, presented in the forward (naturalistic) or backward order. A general group effect terms > preterms for the naturalistic mother’s voice is evident in the theta frequency band in the left temporal area, where only full-term newborns showed an increased activity for the mother’s voice, whereas preterm infants showed significant activation for stranger naturalistic speech. Similarly, a significant group contrast in the low and high theta in the right temporal regions indicates higher activations for the stranger’s speech in preterms. Finally, only full-term newborns presented a late gamma band increase for the maternal naturalistic speech, indicating a more mature brain response.The current study based on neural time-frequency patterns, demonstrates that preterm infants lack selective brain responses to mother’s naturalistic voice typical for full-term newborns, whereas preterms are selectively responsive to stranger voices in both temporal hemispheres.