Abstract
AbstractDuring infection, pathogens are starved of essential nutrients such as iron and tryptophan by host immune effectors. Without conserved global stress response regulators, how the obligate intracellular bacteriumChlamydia trachomatisarrives at a physiologically similar “persistent” state in response to starvation of either nutrient remains unclear. Here, we report on the iron-dependent regulation of thetrpRBAtryptophan salvage pathway inC. trachomatis. Iron starvation specifically inducestrpBAexpression from a novel promoter element within an intergenic region flanked bytrpRandtrpB.YtgR, the only known iron-dependent regulator inChlamydia,can bind to thetrpRBAintergenic region upstream of the alternativetrpBApromoter to repress transcription. Simultaneously, YtgR binding promotes the termination of transcripts from the primary promoter upstream oftrpR.This is the first description of an iron-dependent mechanism regulating prokaryotic tryptophan biosynthesis that may indicate the existence of novel approaches to gene regulation and stress response inChlamydia.
Publisher
Cold Spring Harbor Laboratory
Cited by
1 articles.
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