Light-mediated planar polarization of cone photoreceptor cilia contributes to visual acuity in mammals

Author:

Housset MichaelORCID,Filion Dominic,Cortes Nelson,Vali Hojatollah,Mandato Craig,Casanova Christian,Cayouette Michel

Abstract

ABSTRACTPlanar cell polarity (PCP) is essential to optimize information processing and functional response in many tissues. While the fly eye is a classic example of PCP, it remains unknown whether PCP exists in the mammalian retina and whether it plays a part in vision. Here we used 3D reconstructions of the mouse retina to show that the basal body of cone photoreceptor cilia, but not rods, is systematically located on the side of the cell facing the centre of the retina. We further show that light is required during a critical window of development to establish cone PCP, and that both cone transducin and the G-protein signaling modulator protein 2 are required to mediate this effect. Importantly, we report that disruption of cone PCP impairs visual acuity. This work uncovers a non-canonical PCP pathway, mediated by light, and identifies cone PCP as a feature supporting mammalian vision.

Publisher

Cold Spring Harbor Laboratory

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Patterning and Development of Photoreceptors in the Human Retina;Frontiers in Cell and Developmental Biology;2022-04-14

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