Mechanisms Underlying the Complex Dynamics of Temperature Entrainment by a Circadian Clock

Author:

Burt Philipp,Grabe Saskia,Madeti Cornelia,Upadhyay Abhishek,Merrow Martha,Roenneberg Till,Herzel Hanspeter,Schmal Christoph

Abstract

AbstractAutonomously oscillating circadian clocks resonate with daily environmental (zeitgeber) rhythms to organize physiology around the solar day. While entrainment properties and mechanisms have been studied widely and in great detail for light-dark cycles, entrainment to daily temperature rhythms remains poorly understood despite that they are potent zeitgebers.Here we investigate the entrainment of the chronobiological model organism Neurospora crassa, subject to thermocycles of different periods and fractions of warm versus cold phases, mimicking seasonal variations. Depending on the properties of these thermocycles, regularly entrained rhythms, period-doubling (frequency demultiplication) but also irregular aperiodic behavior occurs. We demonstrate that the complex nonlinear phenomena of experimentally observed entrainment dynamics can be understood by molecular mathematical modeling.Abstract Figure

Publisher

Cold Spring Harbor Laboratory

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