The CADM2 gene and behavior: A phenome-wide scan in UK-Biobank

Author:

A. Pasman JoëlleORCID,Chen Zeli,Vink Jacqueline M.,Van Den Oever Michel C.,Pattij Tommy,Vries Taco J. De,Abdellaoui Abdel,Verweij Karin J.H.

Abstract

AbstractThis phenome-wide association study examined SNP and gene–based associations of the CADM2 gene with 242 psycho-behavioral traits (N=12,211–453,349). We found significant associations with 51 traits, many more than for other genes. We replicated previously reported associations with substance use, risk-taking, and health behavior, and uncovered novel associations with sleep and dietary traits. Accordingly, CADM2 is involved in many psycho-behavioral traits, suggesting a common denominator in their biology.

Publisher

Cold Spring Harbor Laboratory

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